- SNAT - Serotonina Acetil Transferase, a qual converte a Serotonina para N-acetil serotonina e;
- HIOMT - HidroxiIndol-O-Metil Transferase, que transfere um grupo metila da S-adenosilmetionina para a 5-hidroxila da N-acetil serotonina.
“The level of impact [of lighting] on life on the planet… is only now beginning to be appreciated. Of the many potential adverse effects from LAN and circadian disruption on human health, the most evidence to date is on breast cancer. No single study can prove cause and effect, as neither can a group of studies of only one of the factors cited above. However, taken together, the epidemiologic and basic science evidence may lead to a ‘proof’ of causality (i.e. a consensus of experts). If so, then there would be an opportunity for the architectural and lighting communities, working with the scientific community, to develop new lighting technologies that better accommodate the circadian system both at night and during the day inside buildings.”